There, he won a surprising bronze medal at his first senior World Championships, a competition for which his goal had been only to qualify for the free skate.
In the 2005–2006 season, Lysacek again competed on the Grand Prix.
In 2007 he captured the bronze medal at the 2007 International Skating Union (ISU) Grand Prix Final. Though injury forced him to withdraw from the world championships in 2008, Lysacek was victorious at that competition in 2009; he was the first American in 13 years (since Todd Eldredge) to become world champion. At the Yevgeny Plushchenko to become the first American man to win Olympic figure skating gold since Brian Boitano in 1988.
He was the 7th qualifier for the 2000–2001 Junior Grand Prix Final and placed 8th at the Final. Over the next season, Lysacek dealt with several injuries, including broken ribs, which resulted in lost training time. Championships, Lysacek repeated his 12th-place finish from the previous year and was not selected for the team to the 2002 World Junior Championships.
His mother, Tanya (née Santoro), is a substitute teacher in Naperville, and his father, Don, is a building contractor.
He has an older sister, Laura, and a younger sister, Christina, who played on a nationally ranked volleyball team.
His cousin Cole Chason is a former punter for the Clemson Tigers.
Lysacek went to Spring Brook Elementary and then to Gregory Middle School.